The FIFA disciplinary committee, after more than 10 hours of talks over Wednesday night and Thursday morning, banned him from nine competitive Uruguay games and four months of all football activity.
Suarez will miss 13 Liverpool games and any transfer negotiations will not be affected by the ban but would obviously complicate matters, and has been fined £65,000.
Uruguay Football Association president Wilmar Valdez has confirmed the association will lodge an appeal against Luis Suarez's FIFA ban but he will definitely miss tomorrow's last 16 game against Columbia at the Maracana Stadium.
"We are preparing our appeal now, we have three days to do it. It is an excessive decision and there was not enough evidence and I have seen more aggressive incidents recently.
"It is a severe punishment. I don't know exactly which arguments they used but it is a tough punishment for Suarez.
"It's feels like Uruguay has been thrown out of the World Cup. We all know what Suarez means to Uruguay and to football around the world - not having Suarez would be a loss to any team."
Asked if there was any possibility of Uruguay boycotting their last 16 match against Colombia on Saturday, Valdez added: "No, that is not a possibility. Uruguay continues playing at this World Cup. We have good players who can come in."
He added that Suarez will return to Uruguay, saying: "Luis in the next few hours will travel to Montevideo to be with the rest of his family to recover."
The striker's sponsors adidas are holding emergency talks over their stance.
Swiss Claudio Sulser, chairman of the independent disciplinary committee, said: "Such behaviour cannot be tolerated on any football pitch, and in particularly not at a FIFA World Cup when the eyes of millions of people are on the stars on the field.
"The Disciplinary Committee took into account all the factors of the case and the degree of Mr Suarez's guilt in accordance with the relevant provisions of the code.
"The decision comes into affect as soon as it is communicated." This was done to the player and the Uruguay FA shortly before FIFA announced the ban at their daily press briefing in the Maracana.
This restriction is likely to make any Suarez transfer from Liverpool that more difficult until the end of October.
The severity of the sentence came as something of a shock because South American football chiefs, including Argentina President Julio Grondona, were said to have been lobbying hard for a lesser ban.
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