According to a Mail Online, experts believe the 59-year-old is the only person in the world to suffer the rare condition macrodystrophia lipomastosa from shoulder to fingers on both arms, which causes vast build-up of fat deposits to be distributed across her arms and hands.
Moving can be very uncomfortable and even the simplest tasks, such as washing and combing her hair, are extremely difficult for Duangjay.
Embarrassed by her condition throughout her childhood, she spent the first 20 years of her life as a recluse ashamed of the way she looked, meaning she never went to school.
But she was forced to come out of hiding at the age of 20 to earn a living in order to care for her elderly parents, and take over running the family grocery shop.
Duangjay has caught the attention of medics all over the world and many have attempted surgery to decrease the swelling but, to date, none have succeeded.
She said: "My hands are so heavy I can barely lift them to comb or shampoo my hair, it's very difficult. Getting dressed is also very difficult and painful. Some doctors said the only solution was to cut off my hands if I wished to walk around freely. But I don't want to do that."
Growing up she struggled to come to terms with her oversized hands - for which there is no cure - and spent most of childhood avoiding people, skipping school and hiding in the family home.
"My mum told me that I was like this since I was born. I became afraid to go out or go to school, so I never learned to read," she said.
Raised in a rural village in Thailand, there were no medical experts who could provide treatment and Duangjay was so self-conscious that she refused to go out in public.
But when her parents became elderly and unable to work, she had no choice but stop being a recluse and take over the family business.
As news spread of her condition, at age 25 she started undergoing a series of operations to try and solve her problem. But rather than improving the situation, the surgery made the condition worse.
Having undergone two further operations, Duangjay was left in a crippling condition.
Months later she was contacted by a doctor, from Kitasato University in Japan, who flew her to the country for MRI scans and discovered she was suffering from Macrodystrophia Lipomatosa.
Plastic surgeon Dr Eiju Uchinuma said: "This case is very rare. Both her arms are enlarged. Her arms and hands are enormous so they swell badly but it could be worse.
"My diagnosis is that she is the first and only person in the world who has Macrodystrophia Lipomatosa from shoulders to her fingers on both arms. The cause of the disease is unknown and is therefore incurable."
